- Beantown trades Caleb Thielbar and the 2022 BEA #3 Minors Pick to Colorado for Zac Gallen, Rick Porcello and the 2022 COL #9 Minors Pick (January 1, 2022)
- Sudbury trades Zach Plesac and Dinelson Lamet to Beantown for Kenley Jansen and Brad Boxberger (January 4, 2022)
- So Cal trades Cory Seager and Austin Meadows to Cincinnati for Chad Green and Ryne Stanek (January 24, 2022)
- Beantown trades the 2022 BEA #6 Minors Pick and the 2022 BEA #1 prospect pick to Bad News Bears for the 2022 BNB #7 Minors Pick and the 2022 BNB #1 prospect pick (January 25, 2022)
- Beantown trades Jason Castro and the 2022 EGB #9 minors pick to Toronto for the 2022 TOR #6 minors pick (February 5, 2022)
- Chicago trades the 2022 CHI #2 minors pick to Minnesota for alex verdugo and the 2022 MIN #8 Minors Pick (February 6, 2022)
- Edmonton trades Matt Wisler and the 2022 EDM #8 minors pick to NOLA for the 2022 NOL #4 minors pick (February 7, 2022)
- Edmonton trades Mike Mayers and the 2022 EDM #7 minors pick to Chicago for the 2022 CHI #3 minors pick. (February 8, 2022)
- Toronto trades the 2022 TOR # 2 minor pick to Beantown in exchange for Kyle Hendricks, Bobby Dalbec, Eric Hosmer, Kevin Plawecki and the 2022 BEA #5 minors pick (February 9, 2022)
- Goose Island trades the 2022 EDM #5 Minors Pick to Cincinnati for Oscar Mercado and the 2022 CIN #10 Minors Pick (February 28, 2022)
- Toronto trades the 2023 TOR #9 Minors Pick to Sudbury for the 2023 SUD #10 Minors Pick and Carlos Estevez (March 5, 2022)
- So Cal trades Ryne Stanek to Bad News Bears for Tyler Wade (April 2, 2022)
- Toronto trades Kyle Hendricks and Daniel Hudson to Bad News Bears for Trent Grisham, Chad Kuhl and Blake Parker (April 4, 2022)
- Cincinnati trades Austin Meadows, Randal Grichuk, 2023 CIN #1 Minors Pick and the 2023 CIN #2 Minors Pick to Gotham for Jacob deGrom, Kevin Kiermaier, 2023 GOT #9 Minors Pick and the 2023 GOT #10 Minors Pick (April 21, 2022)
- Chicago trades Kyle Seager and the 2023 #10 CHI minors pick to Goose Island for the 2023 GIG #2 Minors Pick (May 1, 2022)
- Narraganset trades Joey Lucchesi, Jordan Holloway, and the 2023 NAR #2 Minors pick to NOLA for Matt Barnes, Deolis Guerra, Patrick Corbin and the 2023 NOL #9 Minors pick (May 22, 2022)
- Narraganset trades Ian Kennedy to Bad News Bears for Amed Rosario (May 22, 2022)
- Gotham trades Clayton Kershaw, Leury Garcia, Archie Bradley and the 2023 GOT #5 Minors Pick to Toronto for Chad Kuhl, Danny Jansen, Yency Almonte and the 2023 TOR #1 Minors Pick (May 29, 2022)
- Woodbury trades Brandon Marsh, Royce Lewis and the 2023 WOO #10 Minors Pick to Goose Island for JT Realmuto and the 2023 GG #4 Minors Pick. Goose Island releases prospect Miguel Yajure. (May 31, 2022)
- EGB trades Yuli Gurriel to Narragansett for Nate Lowe (June 4, 2022)
- Edmonton trades Luis Castillo and Bryce Harper to Maritime for Alek Manoah, Andrew Heaney and Josh Naylor (June 15, 2022)
- Narragansett trades Jarren Duran and Harold Ramirez to Beantown for Jared Walsh and Anthony Rendon (June 25, 2022)
- EGB trades Andrew Kittredge and the 2023 EGB #4 Minors Pick to Narragansett for the 2023 NAR #1 Minors Pick (July 2, 2022)
- NAR trades Corey Dickerson, Anthony Rendon, the 2023 #9 NAR Minors Pick and the 2023 #10 NAR Minors Pick to Toronto for the 2023 TOR #5 Minors Pick and the 2023 #6 TOR Minors Pick (July 2, 2022)
- Maritime trades the 2023 MS #5 Minors Pick to EGB for the 2023 EGB #8 Minors Pick and Richard Rodriguez (July 2, 2022)
- Toronto trades Travis D’Arnaud to Gotham for Mike Zunino and Joe Kelly (July 2, 2022)
- Toronto trades Orlando Arcia , the 2023 TOR #7 Minors Pick and the 2023 TOR #8 minor pick to EGB for Kendal Graveman, Lorenzo Cain, the 2023 EGB #9 Minors Pick and the 2023 EGB #10 Minors Pick (July 2, 2022)
- Nickel City trades Ian Happ and Gavin Lux to EGB for Bryan Reynolds and Santiago Espinal (July 3, 2022)
- EGB trades Marcus Stroman to Minnesota Grain Belt for Nico Hoerner and Spencer Howard (July 3, 2022)
- Gotham trades Lucas Giolito and the 2023 GOT #6 Minors Pick to Maritime for Pablo Lopez and the 2023 MAR #1 Minors Pick (July 3, 2022)
- EGB trades Kyle Gibson and the 2023 MS #5 minors pick to Toronto for Dakota Hudson, Dustin May and the 2023 TOR #2 Minors Pick (July 4, 2022)
- Edmonton trades Trevor Richards to Toronto for Cole Irvin (July 4, 2022)
- Narragansett trades Paul Sewald to Beantown for Blake Treinen (July 14, 2022)
- Beantown trades James Karinchak and the 2023 BEA #6 Minors pick to Maritime for the 2023 MS #3 Minors Pick (July 15, 2022)
- Beantown trades Bryan De La Cruz, Lucas Sims, and the 2023 BEA #5 Minors Pick to Woodbury for Nabil Crismatt and the 2023 WOO #2 Minors Pick (July 16, 2023)
- Edmonton trades Bo Bichette, KeBryan Hayes, and Alek Manoah to Bad News Bears for Jose Altuve, Ryan McMahon and Ryne Stanek (November 7, 2022)
- Gotham trades Will Smith to Cincinnati for Fransisco Lindor (November 7, 2022)
- Gotham trades Christian Yelich, Andrew Vaughn, the 2023 TOR #1 Minors Pick and the 2023 GOT #4 Minors Pick to Orlando for Sandy Alcantara, the 2023 ORL #6 Minors Pick and the 2023 ORL #7 Minors Pick (November 10, 2023)
- Gotham trades Isiah Kiner-Falefa to Orlando for Luis Guillorme (December 19, 2022)
- Beantown trades Josh Bell and Mike Clevinger to the Orlando for Nathaniel Lowe (December 23, 2022)